GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7714584 | 1 | rs4560537 | chr5:150262586 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.2 | 1.42E-9 | Crohn's disease |
| BLCA | cis | rs6477998 | 1 | rs4560868 | chr9:115985499 | CDC26 | chr9:116029290-116037869:- | 0.42 | 8.28 | 2.04E-15 | Hematology traits |
| BLCA | cis | rs10935120 | 1 | rs4572812 | chr3:134291177 | ANAPC13 | chr3:134196547-134204865:- | -0.51 | -8 | 1.45E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs4572812 | chr3:134291177 | CEP63 | chr3:134204575-134293852:+ | -0.24 | -4.14 | 4.32E-5 | Height |
| BLCA | cis | rs9902453 | 1 | rs4575590 | chr17:28361969 | EFCAB5 | chr17:28256874-28435469:+ | -0.23 | -4 | 7.57E-5 | Coffee consumption (cups per day) |
| BLCA | cis | rs3015469 | 1 | rs4578563 | chr14:51159585 | SAV1 | chr14:51100360-51135023:- | -0.18 | -4.02 | 6.92E-5 | Plasma amyloid beta peptide concentrations (ABx-40) |
| BLCA | cis | rs7714584 | 1 | rs4579248 | chr5:150268151 | LOC134466 | chr5:150310000-150326146:- | 0.54 | 6.74 | 6.0E-11 | Crohn's disease |
| BLCA | cis | rs9902453 | 1 | rs4581755 | chr17:28427898 | EFCAB5 | chr17:28256874-28435469:+ | 0.23 | 3.91 | 0.000108 | Coffee consumption (cups per day) |
| BLCA | cis | rs11723261 | 1 | rs4582105 | chr4:246342 | ZNF718 | chr4:53272-156488:+ | 0.34 | 4.55 | 7.25E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs2243480 | 1 | rs458291 | chr7:65520479 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.19 | 3.41E-5 | Diabetic kidney disease |
| BLCA | cis | rs4604732 | 1 | rs4604732 | chr1:247623872 | LOC148824 | chr1:247687982-247694106:- | 0.26 | 4.06 | 5.91E-5 | Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) |
| BLCA | cis | rs7112513 | 1 | rs4604928 | chr11:117044203 | PCSK7 | chr11:117075789-117102811:- | -0.41 | -5.13 | 4.63E-7 | Protein quantitative trait loci |
| BLCA | cis | rs4606360 | 1 | rs4606360 | chr1:173699007 | ANKRD45 | chr1:173577475-173639001:- | 0.25 | 4.21 | 3.15E-5 | Subjective well-being |
| BLCA | cis | rs4627050 | 1 | rs4627050 | chr11:18822037 | PTPN5 | chr11:18749478-18813389:- | -0.23 | -4.44 | 1.2E-5 | Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) |
| BLCA | cis | rs2243480 | 1 | rs462853 | chr7:65558167 | CCT6P1 | chr7:65216092-65228661:+ | 0.34 | 4.8 | 2.27E-6 | Diabetic kidney disease |